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Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Read article at publisher's site DOI : Bird C. Bottomley A. Bottomley A , Jones L.

Smoking and Breast Cancer Recurrence after Breast Conservation Therapy

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Prior studies have shown earlier recurrence and decreased survival in patients with head and neck cancer who smoked while undergoing radiation therapy. The purpose of the current study was to determine whether smoking status at the time of partial mastectomy and radiation therapy for breast cancer affected recurrence or survival. A single institution retrospective chart review was performed to correlate smoking status with patient demographics, tumor characteristics, and outcomes for patients undergoing partial mastectomy and radiation therapy. There were patients who underwent breast conservation surgery between and for whom smoking history and follow-up data were available. Smoking status was associated with race, patient age, and tumor stage, but not with grade, histology, or receptor status. With a mean follow-up of 45 months, recurrence was significantly higher in current smokers compared to former or never smokers.

Overview of the Randomized Trials of Radiotherapy in Ductal Carcinoma in Situ of the Breast

We'd like to understand how you use our websites in order to improve them. Register your interest. Cancer therapy is increasingly becoming dependent on the ability to target specific molecular pathways that drive disease progression. Consequently, the identification of specific molecular pathways requires the use of companion diagnostic assays that are accurate and reproducible. This review will discuss the data and concerns surrounding pre-analytic variables in the evaluation of breast cancer tissue.
Background: As trials of 5 years of tamoxifen in early breast cancer mature, the relevance of hormone receptor measurements and other patient characteristics to long-term outcome can be assessed increasingly reliably. We report updated meta-analyses of the trials of 5 years of adjuvant tamoxifen. Recurrence and death rate ratios RRs were from log-rank analyses by allocated treatment.
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